High quality 99% purity Tamoxifens CAS:54965-24-1

Tamoxifen is a non steroidal anti estrogen drug, which is widely used in clinical medicine. This is a selective estrogen receptor modulator (SERM) of triphenylene series, which has the characteristics of estrogen agonists and antagonists. Therefore, it can act as estrogen in some tissues and prevent the role of estrogen in other tissues. Tamoxifen is a potent anti estrogen in breast tissue, so it is commonly used to treat hormone sensitive breast cancer in women. In some cases, it is even used as a preventive measure by women with family members with hereditary tendency of breast cancer. Among male bodybuilders and athletes, tamoxifen (unmarked) is usually used to resist the side effects caused by elevated estrogen after the use of some anabolic / androgen steroids.

The main concern of the sports / bodybuilding population is the emergence of male and female breast, or the development of very ugly female breast tissue. The first thing to notice is that there may be swelling or small lump under the nipple. In the absence of surgery, if allowed to develop, it may develop into irreversible male breast development. Estrogen can also lead to an increase in the body's water content, resulting in a significant loss of muscle that begins to look smooth (or even swell) due to the retention of subcutaneous fluid. As men's estrogen levels rise, fat storage may also increase. In fact, the difference in estrogen / androgen ratio is one of the reasons why women have more body fat percentage and fat distribution (hip / thigh) than men.

Tamoxifen also has the ability to increase FSH (follicle stimulating hormone) and LH (luteinizing hormone). This is achieved by blocking the negative feedback inhibition caused by hypothalamic estrogen (through the action of gonadotropin releasing hormone) to promote the release of the above pituitary hormones. This is different from clomid ®（ The functions of clomiphene and cyclofenil are very similar. Tamoxifen can have a positive effect on serum testosterone level because higher released LH can stimulate testicular stromal cells in testis (men) to produce more testosterone. This "testosterone stimulating" effect is an additional benefit when preparing to end the steroid cycle. Since anabolic / androgenic steroids tend to inhibit endogenous testosterone production, tamoxifen can help restore the balance of hormone levels. It is most commonly used as part of a comprehensive post cycle recovery plan (see PCT: Post cycle recovery).

It is worth noting that tamoxifen, like other stilbene compounds, can act as estrogen in the liver. In the regulation of serum cholesterol, liver estrogen is very important. It often supports HDL (good) cholesterol synthesis and low-density lipoprotein cholesterol reduction. Since bodybuilders using steroids have addressed the adverse cardiovascular effects of these drugs, the problem of aromatase inhibitor combinations (which will reduce serum estrogen levels) may not always be the best choice. For example, it may be more desirable to use drugs that prevent the development of men's mammary glands while supporting the improvement of cholesterol levels. It is important to note that tamoxifen is not sufficient to stabilize serum cholesterol at healthy levels through the use of C-17 alpha alkylated oral agents or high doses of steroids. Its effect on cholesterol is only to a certain extent, and can not eliminate the risk of cardiovascular disease caused by the use of contracted / androgen steroids.